Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 12/20 | 0.36 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.33 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.33 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4749155 | 1.00 | AAK1 (0.36) | AAK1KDM4DMAPTP2RX3KCNQ4 | |
| SCHEMBL4746002 | 0.79 | AKR1B1 (0.40) | AAK1KCNQ4KCNQ5 | |
| SCHEMBL4746538 | 0.77 | IDO1 (0.34) | — | |
| SCHEMBL4746540 | 0.77 | IDO1 (0.34) | — | |
| SCHEMBL3750954 | 0.70 | RORC (0.37) | AAK1 | |
| SCHEMBL3750959 | 0.70 | RORC (0.37) | AAK1 | |
| SCHEMBL4745826 | 0.69 | KCNA5 (0.35) | AAK1P2RX3KCNQ4KCNQ5 | |
| SCHEMBL4745710 | 0.69 | KCNA5 (0.35) | AAK1P2RX3KCNQ4KCNQ5 | |
| SCHEMBL857284 | 0.68 | HTT (0.55) | MAPTKCNQ4KCNQ5CYP17A1 | |
| SCHEMBL15837143 | 0.67 | UTS2R (0.43) | KDM4DMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124518-A1 | OXO-DIHYDROISOINDOLE SULFONAMIDE COMPOUNDS AS MODULATORS OF THE CCK2 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-10-16 | — | — | WO | disclosed |