Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 2/20 | 0.49 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.46 |
| ▸ | AAK1 | Q2M2I8 | 5/20 | 0.43 |
| ▸ | MAP3K12 | Q12852 | 4/20 | 0.42 |
| ▸ | KIT | P10721 | 2/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.38 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19937778 | 0.79 | BTK (0.47) | PRMT5WDR77MAP3K12KITAXL | |
| SCHEMBL4746489 | 0.79 | MAPK8 (0.51) | PRMT5WDR77LRRK2AAK1MAP3K12 | |
| SCHEMBL19937614 | 0.76 | PRMT5 (0.49) | PRMT5WDR77MAP3K12 | |
| SCHEMBL21069142 | 0.75 | PRMT5 (0.54) | PRMT5WDR77LRRK2AAK1KIT | |
| SCHEMBL4743347 | 0.74 | PRMT5 (0.56) | PRMT5WDR77LRRK2AAK1KIT | |
| SCHEMBL4200987 | 0.73 | MAPK8 (0.60) | PRMT5WDR77LRRK2AAK1MAP3K12 | |
| SCHEMBL8256245 | 0.73 | CDK8 (0.57) | PRMT5WDR77LRRK2AAK1MAP3K12 | |
| SCHEMBL8258473 | 0.73 | CDK8 (0.57) | PRMT5WDR77LRRK2AAK1MAP3K12 | |
| SCHEMBL4746507 | 0.73 | DYRK1A (0.56) | PRMT5WDR77LRRK2AAK1NEK1 | |
| SCHEMBL4743363 | 0.73 | MAP3K11 (0.58) | PRMT5WDR77LRRK2AAK1NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008110508-A1 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH INAPPROPRIATE IKK1 ACTIVITY | GLAXO GROUP LIMITED (GB) | 2008-09-18 | — | — | WO | claimed |
| WO-2008110508-A1 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH INAPPROPRIATE IKK1 ACTIVITY | GLAXO GROUP LIMITED (GB) | 2008-09-18 | — | — | WO | disclosed |
| WO-2008110508-A1 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH INAPPROPRIATE IKK1 ACTIVITY | GLAXO GROUP LIMITED (GB) | 2008-09-18 | — | — | WO | disclosed |