Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.54 |
| ▸ | RAB9A | P51151 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.48 |
| ▸ | RELA | Q04206 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.46 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.46 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.46 |
| ▸ | MITF | O75030 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24988088 | 0.81 | HTT (0.62) | NPC1RAB9AALDH1A1SMN1; SMN2NFKB1 | |
| SCHEMBL4746047 | 0.76 | ABL1 (0.70) | NPC1RAB9ASMN1; SMN2ABL1 | |
| SCHEMBL25407506 | 0.75 | TMPRSS15 (0.68) | NPC1RAB9ASMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL19921646 | 0.75 | HSD17B10 (0.60) | NPC1RAB9AALDH1A1SMN1; SMN2NFKB1 | |
| SCHEMBL25410164 | 0.75 | TMPRSS15 (0.62) | NPC1RAB9AALDH1A1SMN1; SMN2NFKB1 | |
| SCHEMBL25407170 | 0.74 | TMPRSS15 (0.68) | SMN1; SMN2NFKB1NFKB2RELALMNA | |
| SCHEMBL29947433 | 0.73 | HSD17B1 (0.60) | NPC1RAB9AALDH1A1SMN1; SMN2NFKB1 | |
| SCHEMBL25408657 | 0.73 | TMPRSS15 (0.68) | NPC1RAB9ASMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL24730459 | 0.73 | HSD17B1 (0.60) | NPC1RAB9AALDH1A1SMN1; SMN2NFKB1 | |
| SCHEMBL6631884 | 0.73 | SMN1; SMN2 (0.57) | NPC1RAB9AALDH1A1SMN1; SMN2NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124393-A1 | BENZOTHIAZOLE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2008-10-16 | — | — | WO | disclosed |