Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 4/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA7 | P43166 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 2/20 | 0.35 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.35 |
| ▸ | PSMD11 | O00231 | 1/20 | 0.35 |
| ▸ | PSMD12 | O00232 | 1/20 | 0.35 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.35 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.35 |
| ▸ | PSMD3 | O43242 | 1/20 | 0.35 |
| ▸ | PSMC3 | P17980 | 1/20 | 0.35 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4080761 | 1.00 | LMNA (0.39) | LMNACYP3A4ALOX15AKT1CA1 | |
| SCHEMBL7331724 | 0.86 | PRKCA (0.36) | LMNACYP3A4AKT1 | |
| SCHEMBL7331717 | 0.86 | PRKCA (0.36) | LMNACYP3A4AKT1 | |
| SCHEMBL13841803 | 0.79 | TSHR (0.44) | CA1CA2CA7CA9TSHR | |
| SCHEMBL4746432 | 0.78 | LMNA (0.39) | LMNACYP3A4ALOX15CA1CA2 | |
| SCHEMBL3975996 | 0.75 | PSMB11 (0.37) | LMNACYP3A4ALOX15AKT1CA1 | |
| SCHEMBL3261395 | 0.73 | HTT (0.40) | CA1CA2CA7CA9TSHR | |
| SCHEMBL4747218 | 0.73 | HTT (0.40) | CA1CA2CA7CA9TSHR | |
| SCHEMBL4747216 | 0.73 | HTT (0.40) | CA1CA2CA7CA9TSHR | |
| SCHEMBL5237882 | 0.72 | LMNA (0.58) | LMNAAKT1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008119772-A1 | AMIDE DERIVATIVES AS INHIBITORS OF ASPARTYL PROTEASES | MEDIVIR AB (SE) | 2008-10-09 | — | — | WO | disclosed |