SCHEMBL4746853

CCCCCCCCCCN(CCCCN(CC1CC1CN(CCCCN(CC)S(=O)(=O)c1c(C)cc(C)cc1C)S(=O)(=O)c1c(C)cc(C)cc1C)S(=O)(=O)c1c(C)cc(C)cc1C)S(=O)(=O)c1c(C)cc(C)cc1C

nearest known ligand 0.39

Predicted protein targets (top 14)

	gene	UniProt	supporting neighbours	confidence
▸	CNR2	P34972	2/20	0.36

▸	KMT2A	Q03164	6/20	0.34

▸	MEN1	O00255	5/20	0.34

▸	SMN1; SMN2	Q16637	2/20	0.34

▸	LMNA	P02545	1/20	0.34

▸	KDM4E	B2RXH2	2/20	0.34

▸	SERPINE1	P05121	1/20	0.34

▸	ALDH1A1	P00352	1/20	0.34

▸	VCAM1	P19320	1/20	0.33

▸	THRB	P10828	1/20	0.33

▸	MCHR1	Q99705	1/20	0.33

▸	MAPT	P10636	1/20	0.33

▸	HTT	P42858	1/20	0.33

▸	NPSR1	Q6W5P4	1/20	0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL4744059	0.99	KMT2A (0.35)	CNR2KMT2AMEN1SMN1; SMN2LMNA
SCHEMBL4746051	0.95	KMT2A (0.37)	CNR2KMT2AMEN1SMN1; SMN2LMNA
SCHEMBL14080613	0.87	KMT2A (0.41)	CNR2KMT2AMEN1SMN1; SMN2LMNA
SCHEMBL14080566	0.87	KMT2A (0.41)	CNR2KMT2AMEN1SMN1; SMN2LMNA
SCHEMBL14080627	0.87	KMT2A (0.41)	CNR2KMT2AMEN1SMN1; SMN2LMNA
SCHEMBL14080720	0.86	CNR2 (0.41)	CNR2KMT2AMEN1SMN1; SMN2LMNA
SCHEMBL4746052	0.85	THRB (0.35)	CNR2KMT2AMEN1SMN1; SMN2LMNA
SCHEMBL7509603	0.84	CA1 (0.41)	CNR2KMT2ALMNAKDM4ESERPINE1
SCHEMBL7509594	0.84	CA1 (0.41)	CNR2KMT2ALMNAKDM4ESERPINE1
SCHEMBL7518577	0.84	CA1 (0.41)	CNR2KMT2ALMNAKDM4ESERPINE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2008112251-A1	CYCLOPROPYL-CONTAINING POLYAMINE ANALOGS AS DISEASE THERAPIES	PROGEN PHARMACEUTICALS, INC. (US)	2008-09-18	—	—	WO	disclosed