Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4065342 | 0.83 | L3MBTL1 (0.45) | ADORA2AADORA1KDM4EHSD17B10LMNA | |
| SCHEMBL4749649 | 0.81 | PFKFB3 (0.43) | ADORA2AADORA1KDM4EHSD17B10ALOX5 | |
| SCHEMBL4072063 | 0.78 | MAPK1 (0.40) | ADORA2AADORA1KDM4EHSD17B10LMNA | |
| SCHEMBL4072395 | 0.78 | NPC1 (0.39) | ADORA2AADORA1KDM4EHSD17B10LMNA | |
| SCHEMBL11485963 | 0.76 | HTR1A (0.45) | ADORA2AADORA1KDM4ELMNAALOX5 | |
| SCHEMBL4070664 | 0.75 | KDM4E (0.41) | KDM4EHSD17B10LMNAGAAHPGD | |
| SCHEMBL4074599 | 0.75 | KDM4E (0.40) | ADORA2AADORA1KDM4EHSD17B10LMNA | |
| SCHEMBL4070926 | 0.73 | CYP1A2 (0.43) | KDM4EHSD17B10LMNAGAAHPGD | |
| SCHEMBL4251098 | 0.72 | ADORA2A (0.35) | ADORA2AADORA1KDM4EHSD17B10LMNA | |
| SCHEMBL4070385 | 0.72 | KDM4E (0.42) | ADORA2AKDM4EHSD17B10GAAPDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008123756-A1 | A PHARMACEUTICAL COMPOSITIONS CONTAINING LACTON TYPE PYRIDINE DERIVATIVES AS AN EFFECTIVE INGREDIENT FOR THE PREVENTION AND TREATMENT OF ISCHEMIA | SK CHEMICALS CO., LTD. (KR) | 2008-10-16 | — | — | WO | claimed |