SCHEMBL4749649

SCHEMBL4749649

COc1cccc(-c2cc3c(c(C)n2)C(=O)OCC3)c1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PFKFB3 Q16875 1/20 0.43
PDE4B Q07343 1/20 0.43
HSD17B10 Q99714 2/20 0.41
WDR5 P61964 1/20 0.41
KDM4E B2RXH2 1/20 0.41
NPC1 O15118 1/20 0.41
ALDH1A1 P00352 1/20 0.41
TP53 P04637 1/20 0.41
MAPT P10636 1/20 0.41
HPGD P15428 1/20 0.41
CASP1 P29466 1/20 0.41
RAB9A P51151 1/20 0.41
CASP7 P55210 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
ALOX5 P09917 1/20 0.41
ADORA3 P0DMS8 2/20 0.40
ADORA2B P29275 2/20 0.40
ADORA1 P30542 2/20 0.40
ADORA2A P29274 1/20 0.40
CYP1A2 P05177 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4750253 0.88 BRD4 (0.46) KDM4ENPC1ALDH1A1MAPTHPGD
SCHEMBL4066864 0.83 ALDH1A1 (0.39) PDE4BHSD17B10KDM4ENPC1ALDH1A1
SCHEMBL4749025 0.83 PIK3CA (0.39) PFKFB3PDE4BMAOB
SCHEMBL4747170 0.81 ADORA2A (0.45) PFKFB3HSD17B10KDM4ENPC1ALDH1A1
SCHEMBL4481191 0.77 ALDH1A1 (0.46) HSD17B10KDM4ENPC1ALDH1A1TP53
SCHEMBL11485963 0.76 HTR1A (0.45) KDM4ENPC1ALDH1A1MAPTHPGD
SCHEMBL4073028 0.76 APP (0.36) HSD17B10KDM4EALDH1A1MAPTHPGD
SCHEMBL4064580 0.75 SQOR (0.47) PDE4BHSD17B10KDM4ENPC1ALDH1A1
SCHEMBL4063729 0.75 PDE10A (0.38) HSD17B10KDM4ENPC1ALDH1A1TP53
SCHEMBL4065502 0.72 KDM4E (0.42) HSD17B10KDM4ENPC1ALDH1A1TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008123756-A1 A PHARMACEUTICAL COMPOSITIONS CONTAINING LACTON TYPE PYRIDINE DERIVATIVES AS AN EFFECTIVE INGREDIENT FOR THE PREVENTION AND TREATMENT OF ISCHEMIA SK CHEMICALS CO., LTD. (KR) 2008-10-16 WO claimed
WO-2008123756-A1 A PHARMACEUTICAL COMPOSITIONS CONTAINING LACTON TYPE PYRIDINE DERIVATIVES AS AN EFFECTIVE INGREDIENT FOR THE PREVENTION AND TREATMENT OF ISCHEMIA SK CHEMICALS CO., LTD. (KR) 2008-10-16 WO disclosed