SCHEMBL4747371

SCHEMBL4747371

CC(C)c1cc2ccn(-c3ccc(F)cc3)c(=O)c2c(N2CCCCC2)n1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 2/20 0.34
RAB9A P51151 2/20 0.34
NPSR1 Q6W5P4 2/20 0.34
MCHR1 Q99705 2/20 0.34
NPY5R Q15761 1/20 0.34
EGFR P00533 3/20 0.33
ALDH1A1 P00352 2/20 0.33
MAPT P10636 2/20 0.33
TP53 P04637 2/20 0.33
IDO1 P14902 1/20 0.33
TDO2 P48775 1/20 0.33
IDO2 Q6ZQW0 1/20 0.33
MAOB P27338 1/20 0.33
LMNA P02545 1/20 0.33
ADORA3 P0DMS8 1/20 0.33
ADORA2A P29274 1/20 0.33
ADORA2B P29275 1/20 0.33
ADORA1 P30542 1/20 0.33
DRD2 P14416 1/20 0.33
DRD4 P21917 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4749987 0.83 EGFR (0.42) MCHR1EGFRALDH1A1MAPTMEN1
SCHEMBL5820228 0.83 KCNH2 (0.39) NPC1RAB9ANPSR1MCHR1NPY5R
SCHEMBL5813982 0.80 SYK (0.39) NPY5RALDH1A1MAPTSYKL3MBTL1
SCHEMBL5816427 0.77 GRM2 (0.35) NPY5RALDH1A1MAPTSYKL3MBTL1
SCHEMBL5814919 0.75 KDM5A (0.33) ALDH1A1MAPTMEN1KMT2AL3MBTL1
SCHEMBL4788702 0.73 GRM2 (0.36) RAB9AMAPTTP53MEN1KMT2A
SCHEMBL4750208 0.71 JAK2 (0.43) NPY5RALDH1A1MAPTKDM4EHPGD
SCHEMBL4907061 0.67 EGFR (0.42) MCHR1EGFRALDH1A1MAPTMEN1
SCHEMBL4750620 0.65 RAD51 (0.40) NPC1RAB9AEGFRALDH1A1LMNA
SCHEMBL21785529 0.63 GRM1 (0.41) ALDH1A1TP53GRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008123755-A1 A PHARMACEUTICAL COMPOSITIONS CONTAINING LACTAM TYPE PYRIDINE DERIVATIVES AS AN EFFECTIVE INGREDIENT FOR THE PREVENTION AND TREATMENT OF ISCHEMIA SK CHEMICALS CO., LTD. (KR) 2008-10-16 WO claimed
WO-2006112666-A1 PYRIDINE DERIVATIVES, METHODS OF THEIR PREPARATIONS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME SK CHEMICALS CO., LTD. (KR) 2006-10-26 WO claimed
WO-2006112666-A1 PYRIDINE DERIVATIVES, METHODS OF THEIR PREPARATIONS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME SK CHEMICALS CO., LTD. (KR) 2006-10-26 WO disclosed