Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.36 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4907061 | 0.84 | EGFR (0.42) | EGFRHIF1AMEN1KMT2AALDH1A1 | |
| SCHEMBL4747371 | 0.83 | NPC1 (0.34) | EGFRMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL5813982 | 0.77 | SYK (0.39) | ALDH1A1MAPTKDM4EHPGDGAA | |
| SCHEMBL5814919 | 0.76 | KDM5A (0.33) | MEN1KMT2AALDH1A1MAPTKDM4E | |
| SCHEMBL4788702 | 0.74 | GRM2 (0.36) | MEN1KMT2AMAPTKDM4EPOLB | |
| SCHEMBL5816427 | 0.74 | GRM2 (0.35) | ALDH1A1MAPTKDM4EHPGD | |
| SCHEMBL5821178 | 0.70 | HIF1A (0.39) | HIF1AMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL4750208 | 0.68 | JAK2 (0.43) | ALDH1A1MAPTKDM4EHPGD | |
| SCHEMBL5820228 | 0.67 | KCNH2 (0.39) | EGFRMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL28860292 | 0.67 | ALDH1A1 (0.63) | HIF1AMEN1KMT2AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008123755-A1 | A PHARMACEUTICAL COMPOSITIONS CONTAINING LACTAM TYPE PYRIDINE DERIVATIVES AS AN EFFECTIVE INGREDIENT FOR THE PREVENTION AND TREATMENT OF ISCHEMIA | SK CHEMICALS CO., LTD. (KR) | 2008-10-16 | — | — | WO | claimed |
| WO-2006112666-A1 | PYRIDINE DERIVATIVES, METHODS OF THEIR PREPARATIONS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | SK CHEMICALS CO., LTD. (KR) | 2006-10-26 | — | — | WO | disclosed |