Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.40 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 5/20 | 0.38 |
| ▸ | HTR2B | P41595 | 4/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | HTR1B | P28222 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4746896 | 0.94 | PDGFRB (0.39) | NOS3NOS1NOS2HTR2CHTR1A | |
| SCHEMBL4750047 | 0.94 | SMN1; SMN2 (0.39) | HTR2CHTR1ADRD2DRD1HTR1B | |
| Ammonia Solution, Strong SCHEMBL4750926 | 0.93 | PDGFRB (0.38) | NOS3NOS1NOS2HTR2CHTR1A | |
| SCHEMBL873501 | 0.76 | DRD2 (0.54) | HTR2CHTR1ADRD2DRD1HTR1B | |
| SCHEMBL873500 | 0.76 | DRD2 (0.54) | HTR2CHTR1ADRD2DRD1HTR1B | |
| SCHEMBL4839911 | 0.76 | DRD2 (0.54) | HTR2CHTR1ADRD2DRD1HTR1B | |
| SCHEMBL14157832 | 0.76 | DRD2 (0.54) | HTR2CHTR1ADRD2DRD1HTR1B | |
| SCHEMBL4750927 | 0.75 | PDGFRB (0.41) | NOS3NOS1NOS2HTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL8823809 | 0.74 | DRD2 (0.53) | HTR2CHTR1ADRD2DRD1HTR1B | |
| SCHEMBL4747507 | 0.74 | HTR6 (0.40) | HTR6HTR1ADRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130319-A2 | NOVEL N-TETRAHYDRONAPHTALENE OR N-CHROMANE CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |