Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 2/20 | 0.43 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.40 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4743364 | 0.84 | ALDH1A1 (0.46) | HDAC1HDAC6CYP2C9NPC1RAB9A | |
| SCHEMBL4745518 | 0.84 | HDAC1 (0.47) | HDAC1HDAC6PARP1CTSLCYP2C19 | |
| SCHEMBL3919646 | 0.74 | SMN1; SMN2 (0.49) | PARP1CYP2C19CYP2C9NPC1RAB9A | |
| SCHEMBL18193849 | 0.72 | GAA (0.57) | HDAC1HDAC6CTSLGPR139LMNA | |
| SCHEMBL13981910 | 0.71 | KMT2A (0.78) | HDAC1HDAC6CTSLGPR139LMNA | |
| SCHEMBL27865101 | 0.71 | HDAC1 (0.57) | HDAC1HDAC6PARP1CYP2C19CYP2D6 | |
| SCHEMBL22151093 | 0.70 | HDAC1 (0.56) | HDAC1HDAC6PARP1CTSLGPR139 | |
| SCHEMBL405785 | 0.70 | HDAC1 (0.69) | HDAC1HDAC6PARP1NPC1RAB9A | |
| SCHEMBL30046370 | 0.70 | HDAC1 (0.69) | HDAC1HDAC6PARP1NPC1RAB9A | |
| SCHEMBL29584285 | 0.69 | LMNA (0.52) | HDAC1HDAC6CTSLGPR139LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008107677-A2 | THIADIAZOLE AND OXADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | SENEXIS LIMITED (GB) | 2008-09-12 | — | — | WO | disclosed |