SCHEMBL4747692

SCHEMBL4747692

N#Cc1c[nH]c2ncc(-c3cccc(C(=O)NC4CC4)c3)cc12

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TNIK Q9UKE5 4/20 0.63
AXL P30530 4/20 0.51
PIM1 P11309 2/20 0.47
NEK2 P51955 2/20 0.47
STK3 Q13188 2/20 0.47
CDC7 O00311 1/20 0.47
PLK4 O00444 1/20 0.47
CHEK1 O14757 1/20 0.47
AURKA O14965 1/20 0.47
MAPK13 O15264 1/20 0.47
PDPK1 O15530 1/20 0.47
DYRK3 O43781 1/20 0.47
ROCK2 O75116 1/20 0.47
RPS6KA5 O75582 1/20 0.47
PRKD3 O94806 1/20 0.47
PAK4 O96013 1/20 0.47
CHEK2 O96017 1/20 0.47
ABL1 P00519 1/20 0.47
EGFR P00533 1/20 0.47
NTRK1 P04629 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8254990 0.89 TNIK (0.51) TNIKAXLPIM1NEK2STK3
SCHEMBL4747127 0.84 MAPK14 (0.55) TNIKLCKCSF1RKDR
SCHEMBL4743370 0.74 AAK1 (0.55) TNIKAXLPIM1NEK2STK3
SCHEMBL4743697 0.73 PRMT5 (0.53) TNIKAXLPIM1NEK2STK3
SCHEMBL18206006 0.73 TNIK (0.56) TNIKAXLPIM1NEK2STK3
SCHEMBL4745741 0.73 CHUK (0.58) TNIKAXLPIM1NEK2STK3
SCHEMBL13745640 0.72 CAMKK2 (0.67) TNIKAXLPIM1NEK2STK3
SCHEMBL13854128 0.72 MAP4K4 (0.58) TNIKAXLAURKADYRK1ASGK2
SCHEMBL4746451 0.71 BTK (0.56) NTRK1ITKRIPK1
SCHEMBL4746507 0.71 DYRK1A (0.56) CLK2DYRK1ACLK4PRMT5WDR77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008110508-A1 PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH INAPPROPRIATE IKK1 ACTIVITY GLAXO GROUP LIMITED (GB) 2008-09-18 WO claimed
WO-2008110508-A1 PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH INAPPROPRIATE IKK1 ACTIVITY GLAXO GROUP LIMITED (GB) 2008-09-18 WO disclosed
WO-2008110508-A1 PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH INAPPROPRIATE IKK1 ACTIVITY GLAXO GROUP LIMITED (GB) 2008-09-18 WO disclosed