Sulfuric Acid — predicted protein targets

Known targets — ChEMBL curated mechanism

ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C ADRB1 ADRB2 ADRB3 CALCRL CHRM1 CHRM2 CHRM3 F2R MAOA MAOB MAP2K1 MAP2K2 NTRK1 NTRK2 NTRK3 OPRD1 OPRK1 OPRM1 P2RY12 PKLR SCN10A SCN11A SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A SCN9A SLC18A2 SLC6A2 SLC6A3 TLR7 TLR9 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3E TUBA4A TUBB TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB8 dacA dacB dacC folA ftsI mrcA mrcB mrdA pol rplA rplB rplC rplD rplE rplF rplI rplJ rplK rplL rplM rplN rplO rplP rplQ rplR rplS rplT rplU rplV rplW rplX rplY rpmA rpmB rpmB1 rpmB2 rpmC rpmD rpmE rpmE2 rpmF rpmG rpmG1 rpmG2 rpmH rpmI rpmJ rpmJ2 rpsA rpsB rpsC rpsD rpsE rpsF rpsG rpsH rpsI rpsJ rpsK rpsL rpsM rpsN rpsO rpsP rpsQ rpsR rpsR1 rpsR2 rpsS rpsT rpsU rpsZ ykgM ykgO

The experimentally established mechanism targets of Sulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 15)

	gene	UniProt	supporting neighbours	confidence
▸	LMNA	P02545	1/20	0.39

▸	THRB	P10828	1/20	0.39

▸	TSHR	P16473	1/20	0.39

▸	PMP22	Q01453	1/20	0.39

▸	HSD17B10	Q99714	1/20	0.39

▸	DPP4	P27487	2/20	0.38

▸	DPP7	Q9UHL4	2/20	0.38

▸	MAPK1	P28482	1/20	0.37

▸	CPN1	P15169	2/20	0.37

▸	CPB2	Q96IY4	2/20	0.37

▸	F2	P00734	1/20	0.35

▸	CA12	O43570	1/20	0.32

▸	CA1	P00915	1/20	0.32

▸	CA2	P00918	1/20	0.32

▸	CA9	Q16790	1/20	0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL9059345	0.90	—	—
SCHEMBL6221404	0.90	—	—
Sulfuric Acid SCHEMBL2306580	0.82	DPP4 (0.42)	DPP4DPP7CA12CA1CA2
SCHEMBL9387897	0.78	CA12 (0.52)	CPN1CPB2F2CA12CA1
SCHEMBL9059444	0.78	CA12 (0.52)	CPN1CPB2F2CA12CA1
SCHEMBL9147164	0.78	CA12 (0.52)	CPN1CPB2F2CA12CA1
SCHEMBL2527566	0.77	F2 (0.52)	DPP4CPN1CPB2F2
SCHEMBL9059677	0.77	F2 (0.52)	DPP4CPN1CPB2F2
Hydrochloric Acid SCHEMBL2523756	0.74	F2 (0.50)	DPP4CPN1CPB2F2
SCHEMBL2724587	0.73	—	—

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-20080234300-A1	Pyrimido[5,4-c] Quinoline-2, 4-Diamine Derivatives and Methods of Use Thereof	WYETH (US)	2008-09-25	—	—	US	disclosed
WO-2008109599-A1	PYRIMIDO [5,4-C] QUINOLINE-2, 4-DIAMINE DERIVATIVES AND METHODS OF USE THEREOF	WYETH (US)	2008-09-12	—	—	WO	disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

Patent	Title	Text reads most about	Predicted target · text-rank
US-20080234300-A1	Pyrimido[5,4-c] Quinoline-2, 4-Diamine Derivatives and Methods of Use Thereof	DCK, PDK4, PDK2	LMNA 3144/4885THRB 4466/4885TSHR 3606/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.