Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 1/20 | 0.62 |
| ▸ | MAOB | P27338 | 2/20 | 0.52 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.48 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.48 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.48 |
| ▸ | SGK1 | O00141 | 1/20 | 0.46 |
| ▸ | AXL | P30530 | 1/20 | 0.46 |
| ▸ | CDK8 | P49336 | 1/20 | 0.46 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | KIT | P10721 | 2/20 | 0.44 |
| ▸ | NSD2 | O96028 | 1/20 | 0.43 |
| ▸ | AS3MT | Q9HBK9 | 1/20 | 0.43 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4747758 | 0.79 | PRMT5 (0.55) | PRMT5WDR77AAK1SGK1AXL | |
| SCHEMBL15554379 | 0.78 | KIT (0.53) | SGK1AXLCDK8TNIKKIT | |
| SCHEMBL27708665 | 0.77 | IMPDH2 (1.00) | IMPDH2MAOBMAPTNSD2AS3MT | |
| SCHEMBL5857843 | 0.77 | IMPDH2 (0.81) | IMPDH2MAOBMEN1MAPTKMT2A | |
| SCHEMBL4743685 | 0.77 | PRMT5 (0.50) | PRMT5WDR77AAK1SGK1AXL | |
| SCHEMBL21069142 | 0.76 | PRMT5 (0.54) | PRMT5WDR77AAK1AXLCDK8 | |
| SCHEMBL4200987 | 0.74 | MAPK8 (0.60) | PRMT5WDR77AAK1AXLCDK8 | |
| SCHEMBL4744137 | 0.74 | PRMT5 (0.54) | PRMT5WDR77AAK1SGK1AXL | |
| SCHEMBL4199507 | 0.74 | CAMKK2 (0.61) | PRMT5WDR77AAK1AXLCDK8 | |
| SCHEMBL858648 | 0.73 | CDK8 (0.67) | AXLCDK8GSK3BNSD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008110508-A1 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH INAPPROPRIATE IKK1 ACTIVITY | GLAXO GROUP LIMITED (GB) | 2008-09-18 | — | — | WO | claimed |
| WO-2008110508-A1 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH INAPPROPRIATE IKK1 ACTIVITY | GLAXO GROUP LIMITED (GB) | 2008-09-18 | — | — | WO | disclosed |
| WO-2008110508-A1 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH INAPPROPRIATE IKK1 ACTIVITY | GLAXO GROUP LIMITED (GB) | 2008-09-18 | — | — | WO | disclosed |