Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNK | O75909 | 2/20 | 0.62 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.62 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.50 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.50 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.50 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.50 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.50 |
| ▸ | PRKCI | P41743 | 4/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | CDK4 | P11802 | 1/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.47 |
| ▸ | CCND1 | P24385 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | CCND3 | P30281 | 1/20 | 0.47 |
| ▸ | NUDT1 | P36639 | 4/20 | 0.47 |
| ▸ | JAK2 | O60674 | 3/20 | 0.45 |
| ▸ | IKBKB | O14920 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4751329 | 0.92 | TLR8 (0.57) | CCNKCDK12TLR9TLR8TLR7 | |
| SCHEMBL14020099 | 0.92 | CCNK (0.58) | CCNKCDK12AURKBAURKAINCENP | |
| SCHEMBL31420118 | 0.92 | CCNK (0.58) | CCNKCDK12AURKBAURKAINCENP | |
| SCHEMBL20849864 | 0.77 | CCNK (1.00) | CCNKCDK12AURKBAURKAINCENP | |
| SCHEMBL31240700 | 0.73 | CLK2 (0.58) | JAK2CLK2JAK3DYRK1A | |
| SCHEMBL4540461 | 0.73 | DYRK1B (0.55) | CCNA2CDK2JAK2DAPK3PRKD3 | |
| SCHEMBL31240621 | 0.73 | JAK2 (0.50) | AURKBAURKAPRKCICDK1CDK2 | |
| SCHEMBL26686361 | 0.72 | IKBKB (0.51) | AURKBCDK1CDK2JAK2IKBKB | |
| SCHEMBL26888731 | 0.72 | CLK2 (0.51) | AURKBCDK1CDK2JAK2DAPK3 | |
| SCHEMBL31240519 | 0.72 | TBK1 (0.51) | PRKCIJAK2CLK2JAK3DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008132121-A1 | LH-INDAZOLE-3-AMINE COMPOUNDS AS IKK1 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2008-11-06 | — | — | WO | claimed |
| WO-2008132121-A1 | LH-INDAZOLE-3-AMINE COMPOUNDS AS IKK1 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2008-11-06 | — | — | WO | disclosed |