Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 5/20 | 0.57 |
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.57 |
| ▸ | TLR9 | Q9NR96 | 4/20 | 0.57 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.54 |
| ▸ | JAK2 | O60674 | 6/20 | 0.52 |
| ▸ | JAK1 | P23458 | 1/20 | 0.50 |
| ▸ | TYK2 | P29597 | 1/20 | 0.50 |
| ▸ | JAK3 | P52333 | 1/20 | 0.50 |
| ▸ | PRKCQ | Q04759 | 6/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | CCNK | O75909 | 1/20 | 0.48 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4748259 | 0.92 | CCNK (0.62) | TLR8TLR7TLR9NUDT1CHEK1 | |
| SCHEMBL31420118 | 0.81 | CCNK (0.58) | NUDT1CHEK1JAK2JAK1TYK2 | |
| SCHEMBL14020099 | 0.81 | CCNK (0.58) | NUDT1CHEK1JAK2JAK1TYK2 | |
| SCHEMBL31240700 | 0.80 | CLK2 (0.58) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL26686361 | 0.79 | IKBKB (0.51) | JAK2JAK1TYK2JAK3ROCK2 | |
| SCHEMBL26888731 | 0.79 | CLK2 (0.51) | JAK2JAK1TYK2JAK3ROCK2 | |
| SCHEMBL31240621 | 0.77 | JAK2 (0.50) | JAK2JAK1TYK2JAK3ROCK2 | |
| SCHEMBL31240523 | 0.77 | CLK2 (0.67) | JAK2 | |
| SCHEMBL26686456 | 0.76 | JAK2 (0.55) | JAK2JAK1TYK2JAK3ROCK2 | |
| SCHEMBL31420209 | 0.76 | NUDT1 (0.57) | NUDT1JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008132121-A1 | LH-INDAZOLE-3-AMINE COMPOUNDS AS IKK1 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2008-11-06 | — | — | WO | disclosed |
| WO-2008132121-A1 | LH-INDAZOLE-3-AMINE COMPOUNDS AS IKK1 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2008-11-06 | — | — | WO | disclosed |