Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.49 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.48 |
| ▸ | FEN1 | P39748 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1847760 | 0.88 | USP2 (0.70) | USP2TP53SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL8984584 | 0.81 | ERCC5 (0.60) | USP2TP53ALDH1A1KMT2ANPC1 | |
| SCHEMBL6295186 | 0.79 | USP2 (0.70) | USP2TP53SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL4779632 | 0.79 | SMN1; SMN2 (0.62) | USP2TP53SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL16162267 | 0.77 | TP53 (0.67) | USP2TP53SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL1849729 | 0.77 | RAB9A (0.62) | USP2TP53SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL485122 | 0.75 | HSP90AA1 (0.71) | USP2TP53SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL17952713 | 0.75 | RAB9A (0.59) | USP2TP53ALDH1A1KMT2ANPC1 | |
| SCHEMBL1848693 | 0.74 | SMN1; SMN2 (0.65) | USP2TP53SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL580634 | 0.73 | USP2 (0.71) | USP2TP53SMN1; SMN2ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008123821-A1 | 4, 5-DIHYDRO-LH-IMIDAZOL-2-AMINE DERIVATIVES FOR USE IN THE TREATMENT OF RESPIRATORY, CARDIOVASCULAR, NEUROLOGICAL OR GASTROINTESTINAL DISORDERS | ALBIREO AB (SE) | 2008-10-16 | — | — | WO | disclosed |