Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | CBX7 | O95931 | 1/20 | 0.53 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.53 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 1/20 | 0.53 |
| ▸ | CES2 | O00748 | 1/20 | 0.51 |
| ▸ | CES1 | P23141 | 1/20 | 0.51 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.51 |
| ▸ | P4HB | P07237 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27572327 | 0.87 | ALDH1A1 (0.63) | RAB9ACES2CES1SMPD1NPC1 | |
| SCHEMBL6207604 | 0.84 | RAB9A (0.59) | RAB9ANPC1POLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL6210030 | 0.84 | RAB9A (0.59) | RAB9ANPC1POLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL1515775 | 0.84 | MEN1 (0.61) | RAB9ACES2CES1NPC1SMN1; SMN2 | |
| SCHEMBL2477853 | 0.80 | LMNA (0.54) | RAB9ACES2CES1NPC1SMN1; SMN2 | |
| SCHEMBL2768472 | 0.80 | CYP11B1 (0.48) | RAB9ASMPD1NPC1MAPTKMT2A | |
| SCHEMBL18326345 | 0.79 | MEN1 (0.62) | RAB9ACES2CES1NPC1POLB | |
| SCHEMBL25196861 | 0.79 | SMPD1 (0.62) | RAB9ASMPD1 | |
| SCHEMBL30391457 | 0.79 | SMPD1 (0.62) | RAB9ASMPD1 | |
| SCHEMBL1515736 | 0.79 | CTBP2 (0.54) | RAB9ANPC1POLBSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008123821-A1 | 4, 5-DIHYDRO-LH-IMIDAZOL-2-AMINE DERIVATIVES FOR USE IN THE TREATMENT OF RESPIRATORY, CARDIOVASCULAR, NEUROLOGICAL OR GASTROINTESTINAL DISORDERS | ALBIREO AB (SE) | 2008-10-16 | — | — | WO | disclosed |