Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
| ▸ | CTSG | P08311 | 1/20 | 0.42 |
| ▸ | CTRC | Q99895 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | GMNN | O75496 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9260455 | 0.79 | MAPT (0.43) | LMNAADORA3MAPTL3MBTL1KMT2A | |
| SCHEMBL8726371 | 0.79 | KMT2A (0.54) | MAPTL3MBTL1KMT2AMGLLPOLB | |
| SCHEMBL21387269 | 0.76 | MAPT (0.41) | LMNAADORA3MAPTL3MBTL1KMT2A | |
| SCHEMBL5147348 | 0.76 | KMT2A (0.47) | LMNAADORA3MAPTL3MBTL1KMT2A | |
| SCHEMBL1362913 | 0.74 | LMNA (0.47) | LMNAADORA3MAPTKMT2AF2 | |
| SCHEMBL22063690 | 0.74 | LMNA (0.47) | LMNAADORA3MAPTKMT2AF2 | |
| SCHEMBL8726551 | 0.74 | MAPT (0.71) | LMNAMAPTL3MBTL1KMT2AALDH1A1 | |
| SCHEMBL9826491 | 0.74 | KMT2A (0.40) | MAPTL3MBTL1KMT2A | |
| SCHEMBL1362950 | 0.73 | LMNA (0.46) | LMNAADORA3MAPTL3MBTL1KMT2A | |
| SCHEMBL28840093 | 0.72 | LMNA (0.45) | LMNAADORA3MAPTKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113906018-B | Bradykinin B2 receptor antagonists | 法瓦里斯有限责任公司 | 2024-04-12 | — | — | CN | disclosed |
| EP-3983402-A1 | 1-((S)-1-(3-CHLORO-5-FLUORO-2-((4-(1H-PYRAZOL-1-YL)-2-METHYLQUINOLIN-8-YLOXY)METHYL)PHENYL)ETHYL)-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ (BK) B2 RECEPTOR ANTAGONIST FOR TREATING SKIN DISEASES | Pharvaris GmbH (CH) | 2022-04-20 | — | — | EP | disclosed |
| EP-3383860-B1 | APELIN RECEPTOR AGONISTS AND METHODS OF USE | BRISTOL MYERS SQUIBB CO (US) | 2021-01-20 | — | — | EP | disclosed |
| EP-3331872-B1 | NOVEL SUBSTITUTED GLYCINE DERIVED FXIA INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2019-09-25 | — | — | EP | disclosed |
| EP-2958897-A2 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | Senomyx, Inc. (US) | 2015-12-30 | — | — | EP | disclosed |
| WO-2014130582-A2 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | SENOMYX, INC. (US) | 2014-08-28 | — | — | WO | disclosed |
| CN-1129942-B | Aza spiro-compounds acting on the cholinergic system with muscarinic agonist activity | ISRAEL INST BIOLOG RES | 2011-08-10 | — | — | CN | disclosed |
| WO-2008136842-A1 | POLY( CARBONATE-CO-UREA) COPOLYMERS | SABIC INNOVATIVE PLASTICS IP B.V. (NL) | 2008-11-13 | — | — | WO | disclosed |
| CN-1129942-A | Aza spiro-compounds acting on the cholinergic system with muscarinic agonist activity | ISRAEL INST BIOLOG RES (IL) | 1996-08-28 | — | — | CN | disclosed |