Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HEXA | P06865 | 1/20 | 0.31 |
| ▸ | HEXB | P07686 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12478369 | 0.86 | KMT2A (0.51) | KMT2AMAPTL3MBTL1HEXAHEXB | |
| SCHEMBL8726371 | 0.78 | KMT2A (0.54) | KMT2AMAPTL3MBTL1POLBGAA | |
| SCHEMBL4748698 | 0.76 | LMNA (0.48) | KMT2AMAPTL3MBTL1LMNAADORA3 | |
| SCHEMBL9260455 | 0.74 | MAPT (0.43) | KMT2AMAPTL3MBTL1LMNAADORA3 | |
| SCHEMBL24796129 | 0.73 | HEXA (0.34) | HEXAHEXB | |
| SCHEMBL26744408 | 0.73 | HEXA (0.34) | HEXAHEXB | |
| SCHEMBL21389207 | 0.73 | HEXA (0.34) | HEXAHEXB | |
| SCHEMBL8898505 | 0.72 | KMT2A (0.42) | KMT2AMAPTL3MBTL1 | |
| SCHEMBL21387269 | 0.71 | MAPT (0.41) | KMT2AMAPTL3MBTL1LMNAADORA3 | |
| SCHEMBL8726551 | 0.69 | MAPT (0.71) | KMT2AMAPTL3MBTL1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | disclosed |