Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 1/20 | 0.60 |
| ▸ | NOS3 | P29474 | 2/20 | 0.56 |
| ▸ | NOS1 | P29475 | 2/20 | 0.56 |
| ▸ | NOS2 | P35228 | 1/20 | 0.56 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | IDO1 | P14902 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | CLK1 | P49759 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 2/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.50 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.50 |
| ▸ | MET | P08581 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5216603 | 0.82 | NOS3 (0.60) | NOS3NOS1NOS2IDO1HTT | |
| SCHEMBL22639912 | 0.82 | HTT (0.64) | CASRNOS3NOS1NOS2IDO1 | |
| SCHEMBL5212987 | 0.80 | ALDH1A1 (0.68) | NOS3NOS1NOS2IDO1KMT2A | |
| SCHEMBL22639860 | 0.79 | KMT2A (0.66) | CASRNOS3NOS1NOS2IDO1 | |
| SCHEMBL8350666 | 0.78 | AURKB (0.78) | AURKB | |
| SCHEMBL6919054 | 0.77 | AURKB (0.77) | AURKB | |
| SCHEMBL22639710 | 0.77 | IDO1 (0.56) | NOS3NOS1NOS2HSD17B10IDO1 | |
| SCHEMBL22640029 | 0.76 | MET (0.54) | CASRNOS3NOS1NOS2IDO1 | |
| SCHEMBL19921646 | 0.75 | HSD17B10 (0.60) | HSD17B10SMN1; SMN2POLBALDH1A1MAPT | |
| SCHEMBL613934 | 0.74 | ABL1 (0.69) | HTTCLK1KMT2ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124393-A1 | BENZOTHIAZOLE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2008-10-16 | — | — | WO | disclosed |