Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4751664 | 0.95 | RAPGEF4 (0.33) | PKMKCNH2RAPGEF4CYP1A2CYP2C19 | |
| SCHEMBL4105032 | 0.87 | LRRK2 (0.37) | PKMKCNH2RAPGEF4CYP1A2CYP2C19 | |
| SCHEMBL4115341 | 0.86 | RAPGEF4 (0.33) | PKMKCNH2RAPGEF4CYP1A2CYP2C19 | |
| SCHEMBL4751277 | 0.84 | AR (0.40) | — | |
| SCHEMBL4751023 | 0.83 | KCNH2 (0.37) | PKMKCNH2RAPGEF4CYP1A2CYP2C19 | |
| SCHEMBL4751578 | 0.79 | KDM4E (0.37) | RAPGEF4LRRK2POLBMAPK1LMNA | |
| SCHEMBL4098740 | 0.78 | LRRK2 (0.34) | KCNH2CYP1A2CYP2C19SMN1; SMN2LRRK2 | |
| SCHEMBL14538333 | 0.77 | RAPGEF4 (0.38) | KCNH2RAPGEF4CYP2C19LRRK2CYP3A4 | |
| SCHEMBL4911915 | 0.76 | KCNH2 (0.33) | KCNH2CYP1A2CYP2C19SMN1; SMN2POLB | |
| SCHEMBL4103776 | 0.76 | PKM (0.34) | PKMRAPGEF4CYP1A2CYP2C19SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008135824-A1 | OXYALKYLPYRAZOLE COMPOUNDS USEFUL IN THERAPY | PFIZER LIMITED (GB) | 2008-11-13 | — | — | WO | disclosed |