Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | THRB | P10828 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4729504 | 0.85 | CXCL8 (0.62) | POLBTHRBMAPTKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL4733095 | 0.84 | CYP2C9 (0.60) | POLBTHRBMAPTKMT2AMEN1 | |
| SCHEMBL4734517 | 0.82 | POLB (0.60) | POLBTHRBMAPTKMT2AMEN1 | |
| SCHEMBL8066565 | 0.81 | NR4A2 (0.58) | POLBMAPTKMT2ATDP1GAA | |
| SCHEMBL4729232 | 0.80 | POLB (0.63) | POLBTHRBMAPTKMT2AMEN1 | |
| SCHEMBL21121619 | 0.80 | POLB (0.67) | POLBTHRBMAPTKMT2AMEN1 | |
| SCHEMBL11194879 | 0.79 | POLB (0.54) | POLBTHRBMAPTKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL22029285 | 0.78 | POLB (0.65) | POLBTHRBMAPTKMT2AMEN1 | |
| SCHEMBL4730108 | 0.78 | CYP1A2 (0.73) | POLBTHRBMAPTKMT2AMEN1 | |
| SCHEMBL598101 | 0.78 | CYP1A2 (0.65) | POLBTHRBMAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008135886-A2 | QUINOLINE DERIVATIVES FOR USE IN THE INHIBITION OF THE GROWTH OF TUMOUR CELLS | UNIVERSITY OF PRETORIA (ZA) | 2008-11-13 | — | — | WO | disclosed |