Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ELANE | P08246 | 3/20 | 0.41 |
| ▸ | AMPD2 | Q01433 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | EP300 | Q09472 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4751071 | 1.00 | ALDH1A1 (0.43) | ALDH1A1ELANEAMPD2MEN1KMT2A | |
| SCHEMBL10663025 | 0.72 | EHMT2 (0.45) | ALDH1A1ELANEAMPD2MEN1KMT2A | |
| SCHEMBL22554949 | 0.70 | ELANE (0.35) | ALDH1A1ELANEHSD11B1GAA | |
| SCHEMBL6049149 | 0.70 | ALDH1A1 (0.50) | ALDH1A1ELANEAMPD2MEN1KMT2A | |
| SCHEMBL10720438 | 0.69 | EHMT2 (0.39) | ALDH1A1ELANEAMPD2MEN1KMT2A | |
| SCHEMBL11217210 | 0.69 | EHMT2 (0.42) | ALDH1A1ELANEAMPD2MEN1KMT2A | |
| SCHEMBL27829636 | 0.69 | CYP3A4 (0.44) | ALDH1A1ELANEAMPD2MEN1KMT2A | |
| SCHEMBL17063254 | 0.69 | AMPD2 (0.44) | ALDH1A1ELANEAMPD2KMT2AHSD11B1 | |
| SCHEMBL10947846 | 0.68 | AMPD2 (0.43) | ALDH1A1ELANEAMPD2MEN1KMT2A | |
| SCHEMBL21328320 | 0.68 | SIGMAR1 (0.46) | ALDH1A1ELANEMEN1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008135525-A2 | SUBSTITUTED AZETIDINES, MANUFACTURING AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-11-13 | — | — | WO | disclosed |