Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 3/20 | 0.58 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.58 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.58 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.58 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.58 |
| ▸ | DAO | P14920 | 1/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 8/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.48 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.48 |
| ▸ | HTR7 | P34969 | 2/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.48 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.48 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.48 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.48 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.48 |
| ▸ | PGR | P06401 | 8/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL603514 | 0.92 | CHRM1 (0.64) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| Hydrochloric Acid SCHEMBL4635789 | 0.90 | CHRM1 (0.62) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL14365466 | 0.90 | CHRM1 (0.70) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL14041660 | 0.86 | CHRM1 (0.49) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| Hydrochloric Acid SCHEMBL4747177 | 0.85 | CHRM1 (0.48) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| Trifluoroacetic Acid SCHEMBL15575285 | 0.82 | CHRM1 (0.54) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL2636696 | 0.82 | PGR (0.52) | OPRM1PGRTNKS | |
| SCHEMBL14041567 | 0.82 | CHRM1 (0.56) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL2636697 | 0.82 | PGR (0.52) | OPRM1PGRTNKS | |
| SCHEMBL1760904 | 0.81 | OPRM1 (0.57) | CHRM1CHRM2CHRM4CHRM5CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008119712-A1 | BENZOIMIDAZOLE DERIVATIVES WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2008-10-09 | — | — | WO | disclosed |
| WO-2008119712-A1 | BENZOIMIDAZOLE DERIVATIVES WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2008-10-09 | — | — | WO | disclosed |