Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 4/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.54 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.54 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.54 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | PGR | P06401 | 9/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.46 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.46 |
| ▸ | HTR7 | P34969 | 2/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.46 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.46 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.46 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.46 |
| ▸ | TNKS | O95271 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL15574954 | 0.91 | OPRM1 (0.48) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL603514 | 0.89 | CHRM1 (0.64) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| Hydrochloric Acid SCHEMBL4635789 | 0.88 | CHRM1 (0.62) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| Trifluoroacetic Acid SCHEMBL4932146 | 0.82 | CHRM1 (0.82) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL4748990 | 0.82 | CHRM1 (0.58) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| Trifluoroacetic Acid SCHEMBL15575354 | 0.79 | OPRM1 (0.51) | OPRM1OPRD1OPRK1TNKSPARP1 | |
| SCHEMBL1760904 | 0.79 | OPRM1 (0.57) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL4749395 | 0.79 | CHRM1 (0.64) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| Trifluoroacetic Acid SCHEMBL4436898 | 0.78 | OPRM1 (0.52) | CHRM1KCNH2OPRM1DRD2DRD3 | |
| SCHEMBL607235 | 0.78 | OPRM1 (0.53) | CHRM1CHRM2CHRM4CHRM5CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9505749-B2 | Quinazolinone compounds and derivatives thereof | AMGEN INC. (US) | 2016-11-29 | — | — | US | disclosed |
| US-20150225396-A1 | Quinazolinone Compounds and Derivatives Thereof | AMGEN INC. | 2015-08-13 | — | — | US | disclosed |
| EP-2890696-A1 | QUINAZOLINONE COMPOUNDS AND DERIVATIVES THEREOF | AMGEN, INC. (US) | 2015-07-08 | — | — | EP | disclosed |
| WO-2014036022-A1 | QUINAZOLINONE COMPOUNDS AND DERIVATIVES THEREOF | AMGEN INC. (US) | 2014-03-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150225396-A1 | Quinazolinone Compounds and Derivatives Thereof | TNKS, TPI1, TNKS1BP1 | CHRM1 4446/4885CHRM2 4810/4885CHRM4 4741/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.