Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | F7 | P08709 | 1/20 | 0.35 |
| ▸ | F3 | P13726 | 1/20 | 0.35 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.35 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.35 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.35 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.35 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.35 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.35 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.35 |
| ▸ | CACNA1I | Q9P0X4 | 2/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4749099 | 1.00 | POLB (0.38) | POLBKMT2AMEN1HPGDL3MBTL1 | |
| SCHEMBL4749061 | 0.89 | EED (0.37) | POLBKMT2AHPGDL3MBTL1SLC18A3 | |
| SCHEMBL4749058 | 0.89 | EED (0.37) | POLBKMT2AHPGDL3MBTL1SLC18A3 | |
| SCHEMBL4749102 | 0.87 | POLB (0.36) | POLBKMT2AMEN1HPGDL3MBTL1 | |
| SCHEMBL4749201 | 0.86 | MEN1 (0.44) | POLBKMT2AMEN1SLC18A3CACNA1G | |
| SCHEMBL4748993 | 0.86 | MEN1 (0.44) | POLBKMT2AMEN1SLC18A3CACNA1G | |
| SCHEMBL4019762 | 0.84 | MEN1 (0.37) | KMT2AMEN1HPGDGRIN1GRIN2B | |
| SCHEMBL4019759 | 0.84 | MEN1 (0.37) | KMT2AMEN1HPGDGRIN1GRIN2B | |
| SCHEMBL4749422 | 0.82 | HPGD (0.34) | KMT2AHPGDL3MBTL1CACNA1GCACNA1H | |
| SCHEMBL4025206 | 0.81 | NPC1 (0.38) | KMT2AMEN1EEDCYP2D6TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008140810-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2008-11-20 | — | — | WO | disclosed |