Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | CCKBR | P32239 | 1/20 | 0.36 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.36 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.36 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4749201 | 1.00 | MEN1 (0.44) | MEN1KMT2AMAPK1POLBTSHR | |
| SCHEMBL4749102 | 0.89 | POLB (0.36) | MEN1KMT2APOLBTSHRSLC18A3 | |
| SCHEMBL4749099 | 0.86 | POLB (0.38) | MEN1KMT2APOLBTSHRCYP2D6 | |
| SCHEMBL4749101 | 0.86 | POLB (0.38) | MEN1KMT2APOLBTSHRCYP2D6 | |
| SCHEMBL4749058 | 0.85 | EED (0.37) | KMT2AMAPK1POLBTSHRSLC18A3 | |
| SCHEMBL4749061 | 0.85 | EED (0.37) | KMT2AMAPK1POLBTSHRSLC18A3 | |
| SCHEMBL4748988 | 0.84 | MEN1 (0.38) | MEN1KMT2AMAPK1POLBTSHR | |
| SCHEMBL4752708 | 0.82 | MEN1 (0.43) | MEN1KMT2AMAPK1CYP2D6TAAR1 | |
| SCHEMBL4749422 | 0.78 | HPGD (0.34) | KMT2ATSHRCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL4026176 | 0.77 | KMT2A (0.39) | MEN1KMT2AMAPK1CYP2D6TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008140810-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2008-11-20 | — | — | WO | disclosed |