Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CLPP | Q16740 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4752585 | 1.00 | MCHR1 (0.42) | MCHR1RAB9AALDH1A1POLBDRD4 | |
| SCHEMBL4751233 | 0.88 | SIGMAR1 (0.43) | MCHR1ALDH1A1DRD4MEN1KMT2A | |
| SCHEMBL4751231 | 0.88 | SIGMAR1 (0.43) | MCHR1ALDH1A1DRD4MEN1KMT2A | |
| SCHEMBL4751907 | 0.88 | SIGMAR1 (0.43) | MCHR1ALDH1A1DRD4MEN1KMT2A | |
| SCHEMBL608348 | 0.80 | MAPT (0.50) | DRD4MEN1KMT2AATMMAPT | |
| SCHEMBL4788151 | 0.76 | SIGMAR1 (0.45) | RAB9AALDH1A1DRD4MEN1KMT2A | |
| SCHEMBL4748954 | 0.76 | SIGMAR1 (0.45) | RAB9AALDH1A1DRD4MEN1KMT2A | |
| SCHEMBL23995201 | 0.73 | ALDH1A1 (0.50) | MCHR1RAB9AALDH1A1POLB | |
| SCHEMBL5055491 | 0.69 | APP (0.54) | RAB9ADRD4MEN1KMT2AMAPT | |
| SCHEMBL8117468 | 0.69 | MAPT (0.67) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008136754-A1 | NOVEL BENZYL - 2 -OXO-PIPERAZINYL/ 7-OXO/5-OXA- [1,4] DIAZEPANYL/ 2 -OXO- TETRAHYDROPYRIMIDINYL DERIVATIVES | ASTRAZENECA AB (SE) | 2008-11-13 | — | — | WO | disclosed |
| WO-2008136754-A1 | NOVEL BENZYL - 2 -OXO-PIPERAZINYL/ 7-OXO/5-OXA- [1,4] DIAZEPANYL/ 2 -OXO- TETRAHYDROPYRIMIDINYL DERIVATIVES | ASTRAZENECA AB (SE) | 2008-11-13 | — | — | WO | disclosed |