Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
| ▸ | LSS | P48449 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4748954 | 1.00 | SIGMAR1 (0.45) | SIGMAR1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL4751233 | 0.88 | SIGMAR1 (0.43) | SIGMAR1MEN1KMT2AALOX12KDM4E | |
| SCHEMBL4751231 | 0.88 | SIGMAR1 (0.43) | SIGMAR1MEN1KMT2AALOX12KDM4E | |
| SCHEMBL4751907 | 0.88 | SIGMAR1 (0.43) | SIGMAR1MEN1KMT2AALOX12KDM4E | |
| SCHEMBL4749240 | 0.79 | ERCC1 (0.55) | MEN1KMT2AALDH1A1 | |
| SCHEMBL4749176 | 0.76 | MCHR1 (0.42) | MEN1KMT2ARAB9AALDH1A1DRD4 | |
| SCHEMBL4752585 | 0.76 | MCHR1 (0.42) | MEN1KMT2ARAB9AALDH1A1DRD4 | |
| SCHEMBL4752588 | 0.74 | ERCC1 (0.49) | MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL941871 | 0.71 | KDM4E (0.62) | SIGMAR1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL4748931 | 0.69 | P2RX7 (0.48) | KMT2AKDM4EALDH1A1GAAAKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008136754-A1 | NOVEL BENZYL - 2 -OXO-PIPERAZINYL/ 7-OXO/5-OXA- [1,4] DIAZEPANYL/ 2 -OXO- TETRAHYDROPYRIMIDINYL DERIVATIVES | ASTRAZENECA AB (SE) | 2008-11-13 | — | — | WO | claimed |
| WO-2008136754-A1 | NOVEL BENZYL - 2 -OXO-PIPERAZINYL/ 7-OXO/5-OXA- [1,4] DIAZEPANYL/ 2 -OXO- TETRAHYDROPYRIMIDINYL DERIVATIVES | ASTRAZENECA AB (SE) | 2008-11-13 | — | — | WO | disclosed |
| WO-2008136754-A1 | NOVEL BENZYL - 2 -OXO-PIPERAZINYL/ 7-OXO/5-OXA- [1,4] DIAZEPANYL/ 2 -OXO- TETRAHYDROPYRIMIDINYL DERIVATIVES | ASTRAZENECA AB (SE) | 2008-11-13 | — | — | WO | disclosed |