Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.75 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.70 |
| ▸ | PKM | P14618 | 1/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 7/20 | 0.60 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.58 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.58 |
| ▸ | AURKA | O14965 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | MC4R | P32245 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | CLK1 | P49759 | 1/20 | 0.54 |
| ▸ | GSK3A | P49840 | 1/20 | 0.54 |
| ▸ | GSK3B | P49841 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5325876 | 0.92 | TP53 (0.81) | TP53CREBBPKDM4EALDH1A1PKM | |
| SCHEMBL5323732 | 0.91 | CREBBP (0.86) | TP53CREBBPKDM4EALDH1A1PKM | |
| SCHEMBL4749983 | 0.91 | PAX8 (0.68) | TP53CREBBPKDM4EALDH1A1PKM | |
| SCHEMBL3791913 | 0.89 | PAX8 (0.69) | TP53CREBBPKDM4EALDH1A1PKM | |
| SCHEMBL3782313 | 0.88 | MAPT (0.75) | TP53CREBBPKDM4EALDH1A1PKM | |
| SCHEMBL4747226 | 0.86 | PAX8 (0.70) | TP53CREBBPKDM4EALDH1A1PKM | |
| SCHEMBL23493740 | 0.86 | TP53 (1.00) | TP53CREBBPKDM4EALDH1A1PKM | |
| SCHEMBL31307876 | 0.86 | TP53 (1.00) | TP53CREBBPKDM4EALDH1A1PKM | |
| SCHEMBL3656790 | 0.85 | PAX8 (0.69) | TP53CREBBPKDM4EALDH1A1PKM | |
| SCHEMBL3786112 | 0.85 | CREBBP (0.60) | TP53CREBBPKDM4EALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008119771-A2 | QUINOLINE-S-CARBOXYLIC ACID DERIVATIVES AS TYROSINE KINASE INHIBITORS | CLANOTECH AB (SE) | 2008-10-09 | — | — | WO | claimed |
| WO-2008119771-A2 | QUINOLINE-S-CARBOXYLIC ACID DERIVATIVES AS TYROSINE KINASE INHIBITORS | CLANOTECH AB (SE) | 2008-10-09 | — | — | WO | disclosed |
| WO-2008119771-A2 | QUINOLINE-S-CARBOXYLIC ACID DERIVATIVES AS TYROSINE KINASE INHIBITORS | CLANOTECH AB (SE) | 2008-10-09 | — | — | WO | disclosed |