Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.68 |
| ▸ | NPC1 | O15118 | 1/20 | 0.68 |
| ▸ | CRHBP | P24387 | 1/20 | 0.68 |
| ▸ | RAB9A | P51151 | 1/20 | 0.68 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | THRB | P10828 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | RNF4 | P78317 | 1/20 | 0.51 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.51 |
| ▸ | PGR | P06401 | 1/20 | 0.50 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TGM2 | P21980 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18707907 | 0.90 | CYP19A1 (0.54) | HPGDNPC1CRHBPRAB9ACRHR2 | |
| SCHEMBL11536521 | 0.84 | HPGD (0.73) | HPGDNPC1CRHBPRAB9ACRHR2 | |
| SCHEMBL9091689 | 0.81 | RAB9A (1.00) | HPGDNPC1CRHBPRAB9ACRHR2 | |
| SCHEMBL18549331 | 0.80 | MAPT (0.49) | NPC1RAB9AALDH1A1MAPTLMNA | |
| SCHEMBL21430760 | 0.80 | POLB (0.58) | HPGDALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL8512504 | 0.79 | GAA (0.54) | HPGDNPC1CRHBPRAB9ACRHR2 | |
| SCHEMBL9607477 | 0.79 | GAA (0.54) | HPGDNPC1CRHBPRAB9ACRHR2 | |
| SCHEMBL10987231 | 0.77 | MAPT (0.71) | HPGDNPC1CRHBPRAB9ACRHR2 | |
| SCHEMBL11510257 | 0.77 | MAPT (0.71) | HPGDNPC1CRHBPRAB9ACRHR2 | |
| SCHEMBL11715338 | 0.77 | ALDH1A1 (0.68) | HPGDNPC1CRHBPRAB9ACRHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008117079-A1 | ANTIMICROBIAL COMPOUNDS BASED UPON 4-AMINOQUINOLINE | HELPERBY THERAPEUTICS LIMITED (GB) | 2008-10-02 | — | — | WO | disclosed |