Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 1/20 | 0.36 |
| ▸ | TRAP1 | Q12931 | 3/20 | 0.36 |
| ▸ | HSP90B1 | P14625 | 2/20 | 0.36 |
| ▸ | ACHE | P22303 | 3/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | MC4R | P32245 | 2/20 | 0.34 |
| ▸ | MC5R | P33032 | 1/20 | 0.34 |
| ▸ | MC1R | Q01726 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4749425 | 1.00 | PIN1 (0.36) | PIN1TRAP1HSP90B1ACHEKIF11 | |
| SCHEMBL4751580 | 0.88 | KIF11 (0.35) | TRAP1HSP90B1ACHEKIF11KDM4E | |
| SCHEMBL4749430 | 0.88 | KIF11 (0.35) | TRAP1HSP90B1ACHEKIF11KDM4E | |
| SCHEMBL4749258 | 0.87 | KIF11 (0.35) | TRAP1HSP90B1ACHEKIF11GAA | |
| SCHEMBL4749270 | 0.87 | KIF11 (0.35) | TRAP1HSP90B1ACHEKIF11GAA | |
| SCHEMBL4752017 | 0.86 | KIF11 (0.40) | ACHEKIF11KDM4E | |
| SCHEMBL4752081 | 0.84 | KIF11 (0.35) | ACHEKIF11KDM4E | |
| SCHEMBL4751358 | 0.84 | KIF11 (0.35) | ACHEKIF11KDM4E | |
| SCHEMBL4751736 | 0.84 | KIF11 (0.35) | ACHEKIF11KDM4E | |
| SCHEMBL4749505 | 0.84 | KIF11 (0.35) | ACHEKIF11KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008140810-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2008-11-20 | — | — | WO | claimed |
| WO-2008140810-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2008-11-20 | — | — | WO | disclosed |