Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | HRH2 | P25021 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.32 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.32 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.31 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.31 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.31 |
| ▸ | MGLL | Q99685 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4749430 | 1.00 | KIF11 (0.35) | KIF11ACHEHRH2HRH1HSP90B1 | |
| SCHEMBL4752017 | 0.89 | KIF11 (0.40) | KIF11ACHEKDM4E | |
| SCHEMBL4749443 | 0.88 | PIN1 (0.36) | KIF11ACHEHSP90B1TRAP1KDM4E | |
| SCHEMBL4749425 | 0.88 | PIN1 (0.36) | KIF11ACHEHSP90B1TRAP1KDM4E | |
| SCHEMBL4749258 | 0.87 | KIF11 (0.35) | KIF11ACHEHSP90B1TRAP1MGLL | |
| SCHEMBL4749270 | 0.87 | KIF11 (0.35) | KIF11ACHEHSP90B1TRAP1MGLL | |
| SCHEMBL4751821 | 0.85 | MEN1 (0.36) | KIF11ACHEHSP90B1TRAP1KDM4E | |
| SCHEMBL4019728 | 0.85 | TAS1R3 (0.36) | HRH2HRH1TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL4027811 | 0.85 | KDM1A (0.34) | TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL4749505 | 0.84 | KIF11 (0.35) | KIF11ACHEKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008140810-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2008-11-20 | — | — | WO | claimed |
| WO-2008140810-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2008-11-20 | — | — | WO | disclosed |