Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | USP2 | O75604 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 6/20 | 0.60 |
| ▸ | RAB9A | P51151 | 4/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | GLA | P06280 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | GFER | P55789 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | CA12 | O43570 | 1/20 | 0.55 |
| ▸ | CA9 | Q16790 | 1/20 | 0.55 |
| ▸ | PHGDH | O43175 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4749598 | 0.89 | LMNA (0.66) | KDM4EUSP2HPGDTSHRMAPK1 | |
| SCHEMBL4749947 | 0.88 | KDM4E (0.64) | KDM4EUSP2HPGDTSHRMAPK1 | |
| SCHEMBL4749926 | 0.86 | KDM4E (0.74) | KDM4EUSP2HPGDTSHRMAPK1 | |
| SCHEMBL4750786 | 0.85 | KDM4E (0.61) | KDM4EUSP2HPGDTSHRMAPK1 | |
| SCHEMBL4750375 | 0.84 | KDM4E (0.51) | KDM4EUSP2HPGDTSHRMAPK1 | |
| SCHEMBL17073176 | 0.81 | ALDH1A1 (0.62) | KDM4EUSP2HPGDTSHRMAPK1 | |
| SCHEMBL4747451 | 0.80 | KDM4E (0.67) | KDM4EUSP2HPGDTSHRMAPK1 | |
| SCHEMBL4746848 | 0.80 | KDM4E (0.82) | KDM4EUSP2HPGDTSHRMAPK1 | |
| SCHEMBL17073178 | 0.79 | LMNA (0.64) | KDM4EUSP2HPGDTSHRMAPK1 | |
| SCHEMBL4749582 | 0.79 | KDM4E (0.72) | KDM4EUSP2HPGDTSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124000-A2 | THIAZOLE DERIVATIVES AS ANDROGEN RECEPTOR MODULATOR COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2008-10-16 | — | — | WO | claimed |
| WO-2008124000-A2 | THIAZOLE DERIVATIVES AS ANDROGEN RECEPTOR MODULATOR COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2008-10-16 | — | — | WO | disclosed |