Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 9/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4750374 | 0.86 | MAPT (0.49) | KDM4EMAPK1HPGDPOLBSMN1; SMN2 | |
| SCHEMBL4750033 | 0.84 | KDM4E (0.62) | KDM4EMAPK1USP2HPGDTSHR | |
| SCHEMBL4788788 | 0.80 | SMN1; SMN2 (0.54) | KDM4EMAPK1USP2HPGDTSHR | |
| SCHEMBL4749598 | 0.80 | LMNA (0.66) | KDM4EMAPK1USP2HPGDTSHR | |
| SCHEMBL4749947 | 0.79 | KDM4E (0.64) | KDM4EMAPK1USP2HPGDTSHR | |
| SCHEMBL4746914 | 0.79 | SMN1; SMN2 (0.42) | KDM4EMAPK1USP2HPGDTSHR | |
| SCHEMBL4749926 | 0.77 | KDM4E (0.74) | KDM4EMAPK1USP2HPGDTSHR | |
| SCHEMBL4750786 | 0.76 | KDM4E (0.61) | KDM4EMAPK1USP2HPGDTSHR | |
| SCHEMBL17073176 | 0.76 | ALDH1A1 (0.62) | KDM4EMAPK1USP2HPGDTSHR | |
| SCHEMBL17073149 | 0.73 | MAPT (0.63) | KDM4EMAPK1USP2HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124000-A2 | THIAZOLE DERIVATIVES AS ANDROGEN RECEPTOR MODULATOR COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2008-10-16 | — | — | WO | disclosed |
| WO-2008124000-A2 | THIAZOLE DERIVATIVES AS ANDROGEN RECEPTOR MODULATOR COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2008-10-16 | — | — | WO | disclosed |