Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 5/20 | 0.40 |
| ▸ | NOS1 | P29475 | 4/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | NOS3 | P29474 | 2/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4646712 | 0.91 | MAPT (0.43) | NOS2NOS1KITHTTSMN1; SMN2 | |
| SCHEMBL4649493 | 0.87 | NOS2 (0.40) | NOS2NOS1LMNAALDH1A1USP2 | |
| SCHEMBL4750123 | 0.87 | NOS2 (0.44) | NOS2NOS1KITLMNAALDH1A1 | |
| SCHEMBL4647173 | 0.85 | ALDH1A1 (0.53) | ALDH1A1HTTNPC1MAPTMAPK1 | |
| SCHEMBL4647625 | 0.85 | MAPT (0.47) | NOS2NOS1KITS1PR1LMNA | |
| SCHEMBL4647407 | 0.85 | NOS2 (0.44) | NOS2NOS1KITLMNAALDH1A1 | |
| SCHEMBL4647104 | 0.84 | HDAC2 (0.43) | NOS2NOS1KITLMNAALDH1A1 | |
| SCHEMBL4636122 | 0.82 | NOS2 (0.50) | NOS2NOS1KITLMNAALDH1A1 | |
| SCHEMBL4647964 | 0.82 | EPHX2 (0.40) | NOS2NOS1KITLMNAALDH1A1 | |
| SCHEMBL4648472 | 0.80 | CDK1 (0.44) | NOS2NOS1LMNAALDH1A1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960389-A2 | COMPOUNDS WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2008-08-27 | — | — | EP | disclosed |
| WO-2007036718-A2 | COMPOUNDS WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2007-04-05 | — | — | WO | disclosed |