SCHEMBL4648472

SCHEMBL4648472

COc1cc(N)c(NC2CCN(C(=O)OCC(C)C)CC2)cc1C

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK1 P06493 2/20 0.44
CDK4 P11802 2/20 0.44
CCND1 P24385 2/20 0.44
CDK2 P24941 2/20 0.44
NOS2 P35228 5/20 0.43
NOS1 P29475 4/20 0.43
NOS3 P29474 2/20 0.43
MAP4K4 O95819 1/20 0.40
MAPT P10636 2/20 0.40
NPSR1 Q6W5P4 1/20 0.40
USP2 O75604 1/20 0.40
ALDH1A1 P00352 1/20 0.40
LMNA P02545 2/20 0.39
KDM4E B2RXH2 1/20 0.39
HDAC2 Q92769 1/20 0.39
HTR4 Q13639 2/20 0.39
KCNH2 Q12809 1/20 0.39
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4649493 0.91 NOS2 (0.40) CDK1CDK4CCND1CDK2NOS2
SCHEMBL4646712 0.87 MAPT (0.43) CDK1CDK4CCND1CDK2NOS2
SCHEMBL4647277 0.87 HDAC2 (0.43) CDK1CDK4CCND1CDK2NOS2
SCHEMBL4750123 0.87 NOS2 (0.44) CDK1CDK4CCND1CDK2NOS2
SCHEMBL4647407 0.84 NOS2 (0.44) CDK1CDK4CCND1CDK2NOS2
SCHEMBL4646792 0.84 KDM1A (0.42) CDK1CDK4CCND1CDK2NOS2
SCHEMBL4648470 0.82 ALDH1A1 (0.55) MAPTALDH1A1
SCHEMBL4659793 0.82 NOS2 (0.50) CDK1CDK4CCND1CDK2NOS2
SCHEMBL4647178 0.80 NOS2 (0.40) CDK1CDK4CCND1CDK2NOS2
SCHEMBL4648881 0.80 HDAC2 (0.43) CDK1CDK4CCND1CDK2NOS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1960389-A2 COMPOUNDS WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE GLAXO GROUP LIMITED (GB) 2008-08-27 EP disclosed
WO-2007036718-A2 COMPOUNDS WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE GLAXO GROUP LIMITED (GB) 2007-04-05 WO disclosed