SCHEMBL4750210

SCHEMBL4750210

Cc1nc(-c2ccc(F)c(F)c2)cc2ccn(-c3ccc(F)cc3)c(=O)c12

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGFR P00533 1/20 0.39
PTGS2 P35354 2/20 0.37
POLB P06746 2/20 0.36
USP2 O75604 2/20 0.36
CYP1A2 P05177 2/20 0.36
CYP3A4 P08684 2/20 0.36
ALDH1A1 P00352 1/20 0.36
HSD17B10 Q99714 1/20 0.36
LCK P06239 2/20 0.36
KIT P10721 2/20 0.36
SRC P12931 2/20 0.36
KDR P35968 1/20 0.36
PTGS1 P23219 1/20 0.35
MET P08581 3/20 0.35
RAD51 Q06609 1/20 0.34
GRM1 Q13255 2/20 0.34
CYP2C9 P11712 1/20 0.34
TSHR P16473 1/20 0.34
MAPK1 P28482 1/20 0.34
CYP2C19 P33261 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4750620 0.92 RAD51 (0.40) EGFRPTGS2ALDH1A1METRAD51
SCHEMBL4747271 0.91 EGFR (0.37) EGFRPTGS2POLBUSP2CYP1A2
SCHEMBL4750659 0.88 EGFR (0.42) EGFRPTGS2POLBUSP2CYP1A2
SCHEMBL5816238 0.86 ALDH1A1 (0.40) ALDH1A1GRM1MAPK1
SCHEMBL4747315 0.85 EGFR (0.49) EGFRALDH1A1METGRM1CYP2C9
SCHEMBL4750212 0.85 PSD (0.42) EGFRPOLBLCKKITSRC
SCHEMBL4750005 0.84 RAD51 (0.39) EGFRALDH1A1RAD51SMN1; SMN2KDM4C
SCHEMBL5818400 0.82 ZAP70 (0.38) USP2CYP1A2CYP3A4ALDH1A1HSD17B10
SCHEMBL4747261 0.80 EGFR (0.46) EGFRPTGS2ALDH1A1METCYP2C9
SCHEMBL4751098 0.79 GRM2 (0.38) USP2CYP1A2CYP3A4ALDH1A1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008123755-A1 A PHARMACEUTICAL COMPOSITIONS CONTAINING LACTAM TYPE PYRIDINE DERIVATIVES AS AN EFFECTIVE INGREDIENT FOR THE PREVENTION AND TREATMENT OF ISCHEMIA SK CHEMICALS CO., LTD. (KR) 2008-10-16 WO claimed
WO-2008123755-A1 A PHARMACEUTICAL COMPOSITIONS CONTAINING LACTAM TYPE PYRIDINE DERIVATIVES AS AN EFFECTIVE INGREDIENT FOR THE PREVENTION AND TREATMENT OF ISCHEMIA SK CHEMICALS CO., LTD. (KR) 2008-10-16 WO disclosed
WO-2006112666-A1 PYRIDINE DERIVATIVES, METHODS OF THEIR PREPARATIONS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME SK CHEMICALS CO., LTD. (KR) 2006-10-26 WO disclosed