Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.60 |
| ▸ | RAB9A | P51151 | 4/20 | 0.60 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.55 |
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4747038 | 0.86 | SMN1; SMN2 (0.52) | KDM4ERAB9AADORA3SMN1; SMN2LMNA | |
| SCHEMBL4749663 | 0.80 | MAPT (0.68) | RAB9ASMN1; SMN2LMNAALDH1A1MAPK1 | |
| SCHEMBL16607129 | 0.77 | ADORA3 (0.75) | KDM4ERAB9AADORA3SMN1; SMN2LMNA | |
| SCHEMBL4749582 | 0.75 | KDM4E (0.72) | KDM4ERAB9AADORA3SMN1; SMN2LMNA | |
| SCHEMBL4749602 | 0.75 | KDM4E (0.72) | KDM4ERAB9AADORA3SMN1; SMN2LMNA | |
| SCHEMBL4747384 | 0.75 | ROCK1 (0.47) | KDM4ERAB9ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL18425097 | 0.75 | ADORA3 (0.69) | KDM4ERAB9AADORA3SMN1; SMN2LMNA | |
| SCHEMBL4749926 | 0.75 | KDM4E (0.74) | KDM4ERAB9AADORA3SMN1; SMN2LMNA | |
| SCHEMBL14041858 | 0.75 | RAB9A (0.41) | KDM4ERAB9ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL4749789 | 0.75 | KDM4E (0.71) | KDM4ERAB9AADORA3SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124000-A2 | THIAZOLE DERIVATIVES AS ANDROGEN RECEPTOR MODULATOR COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2008-10-16 | — | — | WO | claimed |
| WO-2008124000-A2 | THIAZOLE DERIVATIVES AS ANDROGEN RECEPTOR MODULATOR COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2008-10-16 | — | — | WO | disclosed |