Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 9/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | CLK1 | P49759 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4747038 | 0.90 | SMN1; SMN2 (0.52) | MAPTALDH1A1KDM4EMAPK1HPGD | |
| SCHEMBL4750317 | 0.83 | TLK2 (0.44) | ROCK1MAPTCYP3A4ALDH1A1MAPK1 | |
| SCHEMBL6510207 | 0.80 | HDAC1 (0.55) | MAPTMEN1KMT2APOLB | |
| SCHEMBL4750852 | 0.75 | KDM4E (0.60) | MAPTALDH1A1THRBKDM4EMAPK1 | |
| SCHEMBL4183129 | 0.75 | MEN1 (0.50) | MAPTNPC1MEN1KMT2APOLB | |
| SCHEMBL4476221 | 0.69 | ROCK1 (0.84) | ROCK1ROCK2MAPTCYP3A4ALDH1A1 | |
| SCHEMBL1619487 | 0.69 | CLK1 (0.53) | ROCK1ROCK2PARP1CLK1MAPT | |
| SCHEMBL15757198 | 0.66 | RAB9A (0.56) | MAPTALDH1A1KDM4EUSP2HPGD | |
| SCHEMBL14041985 | 0.66 | ADORA3 (0.55) | CLK1MAPTALDH1A1KDM4EMAPK1 | |
| SCHEMBL31134924 | 0.66 | USP2 (0.54) | MAPTALDH1A1THRBKDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124000-A2 | THIAZOLE DERIVATIVES AS ANDROGEN RECEPTOR MODULATOR COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2008-10-16 | — | — | WO | claimed |
| WO-2008124000-A2 | THIAZOLE DERIVATIVES AS ANDROGEN RECEPTOR MODULATOR COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2008-10-16 | — | — | WO | disclosed |