Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | BLM | P54132 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | ATM | Q13315 | 2/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | GMNN | O75496 | 1/20 | 0.51 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6471909 | 0.77 | ALDH1A1 (0.40) | MEN1ALDH1A1KMT2A | |
| SCHEMBL8955025 | 0.70 | ALDH1A1 (0.63) | MEN1ALDH1A1CYP1A2CYP3A4TSHR | |
| SCHEMBL13280777 | 0.69 | AKR1C4 (0.37) | MEN1ALDH1A1CYP1A2MAPK1KMT2A | |
| SCHEMBL2371710 | 0.68 | ALDH1A1 (1.00) | MEN1ALDH1A1CYP1A2CYP3A4TSHR | |
| SCHEMBL7094520 | 0.67 | ALDH1A1 (0.59) | MEN1ALDH1A1CYP1A2CYP3A4TSHR | |
| SCHEMBL11255493 | 0.66 | LMNA (0.58) | MEN1ALDH1A1CYP1A2CYP3A4TSHR | |
| SCHEMBL11161013 | 0.64 | LMNA (0.54) | MEN1ALDH1A1CYP1A2CYP3A4TSHR | |
| SCHEMBL13956348 | 0.63 | KDM4E (0.55) | MEN1ALDH1A1CYP1A2CYP3A4TSHR | |
| SCHEMBL10604291 | 0.63 | ALDH1A1 (0.80) | MEN1ALDH1A1CYP1A2CYP3A4TSHR | |
| SCHEMBL31610902 | 0.62 | HSP90AB1 (0.65) | MEN1ALDH1A1CYP3A4TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130313-A1 | IMIDAZOLE DERIVATIVES AS MODULATORS OF THE GABA RECEPTOR FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |