Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.56 |
| ▸ | HTR2A | P28223 | 1/20 | 0.56 |
| ▸ | HTR2B | P41595 | 1/20 | 0.56 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | DRD1 | P21728 | 8/20 | 0.46 |
| ▸ | DRD2 | P14416 | 4/20 | 0.46 |
| ▸ | PRCP | P42785 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | DRD5 | P21918 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ADCY6 | O43306 | 1/20 | 0.43 |
| ▸ | ADCY3 | O60266 | 1/20 | 0.43 |
| ▸ | ADCY9 | O60503 | 1/20 | 0.43 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.43 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.43 |
| ▸ | ADCY7 | P51828 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6601826 | 0.85 | HTR2C (0.54) | HTR2CHTR2AHTR2BTAAR1TSHR | |
| SCHEMBL29595365 | 0.83 | MEN1 (0.54) | HTR2ATAAR1TSHRNPSR1DRD1 | |
| SCHEMBL1338359 | 0.83 | MEN1 (0.54) | HTR2ATAAR1TSHRNPSR1DRD1 | |
| SCHEMBL2369359 | 0.81 | HTR2C (0.50) | HTR2CHTR2AHTR2BTAAR1TSHR | |
| Hydrochloric Acid SCHEMBL27476431 | 0.81 | MEN1 (0.53) | HTR2ATAAR1TSHRNPSR1DRD1 | |
| SCHEMBL174199 | 0.79 | TAAR1 (0.45) | HTR2CHTR2AHTR2BTAAR1TSHR | |
| Acetic Acid SCHEMBL27449656 | 0.79 | MEN1 (0.50) | HTR2CHTR2AHTR2BTAAR1TSHR | |
| SCHEMBL4662681 | 0.78 | HTR2C (0.50) | HTR2CHTR2AHTR2BTAAR1TSHR | |
| SCHEMBL907688 | 0.77 | PIN1 (0.60) | TSHRNPSR1 | |
| SCHEMBL2790690 | 0.77 | PIN1 (0.60) | TSHRNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008135524-A2 | SUBSTITUTED ANTHRANILAMIDES AND ANALOGUES, MANUFACTURING AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-11-13 | — | — | WO | disclosed |
| EP-1451176-A2 | BENZAZEPINE DERIVATIVES AND THEIR USE AS 5-HT LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 2004-09-01 | — | — | EP | disclosed |
| WO-2003045940-A2 | BENZAZEPINE DERIVATIVES AND THEIR USE AS 5-HT LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 2003-06-05 | — | — | WO | disclosed |