Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 2/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 3/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4751837 | 1.00 | MEN1 (0.38) | MEN1KMT2AMAPK1MGLLGRIN1 | |
| SCHEMBL4749232 | 0.96 | MGLL (0.37) | MEN1KMT2AMGLLGRIN1GRIN2B | |
| SCHEMBL4749225 | 0.96 | MGLL (0.37) | MEN1KMT2AMGLLGRIN1GRIN2B | |
| SCHEMBL4025347 | 0.96 | KIF11 (0.37) | DRD2KIF11 | |
| SCHEMBL4749359 | 0.95 | MGLL (0.41) | MEN1KMT2AMGLLHTR2ADRD2 | |
| SCHEMBL4752854 | 0.95 | MGLL (0.41) | MEN1KMT2AMGLLHTR2ADRD2 | |
| SCHEMBL4749456 | 0.95 | KIF11 (0.39) | MEN1KMT2AMGLLKIF11 | |
| SCHEMBL4749461 | 0.95 | KIF11 (0.39) | MEN1KMT2AMGLLKIF11 | |
| SCHEMBL4023151 | 0.95 | HTR7 (0.37) | DRD2KIF11 | |
| SCHEMBL4749478 | 0.94 | KIF11 (0.35) | MEN1KMT2AMGLLDRD2KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008140810-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2008-11-20 | — | — | WO | claimed |
| WO-2008140810-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2008-11-20 | — | — | WO | disclosed |