Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.53 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.52 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.45 |
| ▸ | IDO1 | P14902 | 2/20 | 0.44 |
| ▸ | TDO2 | P48775 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CTSV | O60911 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13529659 | 0.85 | MAP2K1 (0.52) | EGFRMAP2K1MAP2K2CSF1RGRM4 | |
| SCHEMBL4748557 | 0.83 | MAP2K1 (0.48) | EGFRMAP2K1MAP2K2CSF1RGRM4 | |
| SCHEMBL4748744 | 0.81 | EGFR (0.39) | EGFRMAP2K1CSF1RGRM4MAPT | |
| SCHEMBL14022253 | 0.81 | RAPGEF4 (0.48) | EGFRCSF1RGRM4IDO1TDO2 | |
| SCHEMBL4748743 | 0.79 | EGFR (0.38) | EGFRMAP2K1CSF1RGRM4IDO1 | |
| SCHEMBL4748555 | 0.79 | MAPT (0.40) | EGFRCSF1RGRM4IDO1TDO2 | |
| SCHEMBL5989971 | 0.76 | MAP2K1 (0.48) | MAP2K1MAP2K2MAPTMEN1LMNA | |
| SCHEMBL14223038 | 0.74 | KMT2A (0.60) | EGFRMAP2K1MAP2K2IDO1TDO2 | |
| SCHEMBL6035217 | 0.73 | MAP2K1 (0.73) | MAP2K1MAP2K2HDAC6 | |
| SCHEMBL15698772 | 0.72 | MAP2K1 (0.56) | MAP2K1MAP2K2MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008132464-A2 | MEK5 AND RELATED PROTEINS AS BIOMARKERS OF NEURODEGENERATIVE DISEASES | THE UNIVERSITY OF NOTTINGHAM (GB) | 2008-11-06 | — | — | WO | disclosed |