Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.39 |
| ▸ | CSF1R | P07333 | 7/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4752089 | 0.81 | EGFR (0.53) | EGFRCSF1RGRM4NPC1MAPT | |
| SCHEMBL4748743 | 0.75 | EGFR (0.38) | EGFRCSF1RGRM4NPC1MAPT | |
| SCHEMBL4748557 | 0.75 | MAP2K1 (0.48) | EGFRCSF1RGRM4MAP2K1 | |
| SCHEMBL14022253 | 0.72 | RAPGEF4 (0.48) | EGFRCSF1RGRM4MAPT | |
| SCHEMBL4748555 | 0.71 | MAPT (0.40) | EGFRCSF1RGRM4MAPTHDAC6 | |
| SCHEMBL4733762 | 0.70 | MAPT (0.49) | NPC1MAPTRAB9AHPGD | |
| SCHEMBL13529659 | 0.68 | MAP2K1 (0.52) | EGFRCSF1RGRM4MAPTMAP2K1 | |
| SCHEMBL14680363 | 0.67 | SMN1; SMN2 (0.47) | NPC1MAPTRAB9AHPGDSMN1; SMN2 | |
| SCHEMBL4805409 | 0.66 | GAA (0.63) | — | |
| SCHEMBL28684503 | 0.65 | KMT2A (0.43) | HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008132464-A2 | MEK5 AND RELATED PROTEINS AS BIOMARKERS OF NEURODEGENERATIVE DISEASES | THE UNIVERSITY OF NOTTINGHAM (GB) | 2008-11-06 | — | — | WO | disclosed |