Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | F2 | P00734 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | PLA2G7 | Q13093 | 2/20 | 0.46 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.46 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.46 |
| ▸ | UNG | P13051 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MIF | P14174 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL475274 | 0.92 | ALDH1A1 (0.69) | ALDH1A1CYP2A6KMT2APARP10PARP3 | |
| SCHEMBL11068409 | 0.92 | ALDH1A1 (0.69) | ALDH1A1CYP2A6KMT2APARP10PARP3 | |
| SCHEMBL8717537 | 0.85 | LMNA (0.67) | ALDH1A1F2LMNATSHRTP53 | |
| Benzaldehyde SCHEMBL27264524 | 0.83 | ALDH1A1 (0.62) | ALDH1A1F2LMNACYP2A6TSHR | |
| Formic Acid SCHEMBL27875019 | 0.83 | LMNA (0.58) | ALDH1A1F2LMNATSHRTP53 | |
| Hydrogen Peroxide SCHEMBL27952375 | 0.82 | LMNA (0.70) | ALDH1A1F2LMNATSHRTP53 | |
| Benzene SCHEMBL27793442 | 0.82 | LMNA (0.70) | ALDH1A1F2LMNATSHRTP53 | |
| SCHEMBL52413 | 0.82 | LMNA (0.70) | ALDH1A1F2LMNATSHRTP53 | |
| SCHEMBL440529 | 0.82 | F2 (0.48) | ALDH1A1F2LMNATSHRTP53 | |
| SCHEMBL18678667 | 0.81 | ALDH1A1 (0.64) | ALDH1A1LMNACYP2A6KMT2AUNG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1933878-B1 | CONJUGATES OF HYDROXYALKYL STARCH AND AN ACTIVE SUBSTANCE, PREPARED BY CHEMICAL LIGATION VIA THIAZOLIDINE | FRESENIUS KABI DE GMBH (DE) | 2012-02-01 | — | — | EP | claimed |
| US-20080207562-A1 | Conjugates of Hydroxyalkyl Starch and Active Substance, Prepared by Chemical Ligation Via Thiazolidine | FRESENIUS KABI DEUTSCHLAND GMBH (DE) | 2008-08-28 | — | — | US | claimed |
| EP-1933878-A2 | CONJUGATES OF HYDROXYALKYL STARCH AND AN ACTIVE SUBSTANCE, PREPARED BY CHEMICAL LIGATION VIA THIAZOLIDINE | Fresenius Kabi Deutschland GmbH (DE) | 2008-06-25 | — | — | EP | claimed |
| WO-2007031266-A2 | CONJUGATES OF HYDROXYALKYL STARCH AND AN ACTIVE SUBSTANCE, PREPARED BY CHEMICAL LIGATION VIA THIAZOLIDINE | FRESENIUS KABI DEUTSCHLAND GMBH (DE) | 2007-03-22 | — | — | WO | claimed |
| EP-1762250-A1 | Conjugates of hydroxyalkyl starch and an active substance, prepared by chemical ligation via thiazolidine | Fresenius Kabi Deutschland GmbH (DE) | 2007-03-14 | — | — | EP | claimed |
| US-9758459-B2 | Allosteric modulators of factor XIa as anticoagulant agents | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2017-09-12 | — | — | US | disclosed |
| US-9758459-B2 | Allosteric modulators of factor XIa as anticoagulant agents | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2017-09-12 | — | — | US | disclosed |
| US-20160311842-A1 | ALLOSTERIC MODULATORS OF FACTOR XIa AS ANTICOAGULANT AGENTS | VIRGINIA COMMONWEALTH UNIVERSITY | 2016-10-27 | — | — | US | disclosed |
| US-20160311842-A1 | ALLOSTERIC MODULATORS OF FACTOR XIa AS ANTICOAGULANT AGENTS | VIRGINIA COMMONWEALTH UNIVERSITY | 2016-10-27 | — | — | US | disclosed |
| WO-2014075045-A1 | ALLOSTERIC MODULATORS OF FACTOR XIa AS ANTICOAGULANT AGENTS | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2014-05-15 | — | — | WO | disclosed |
| US-8263548-B2 | Metal-binding compounds and uses therefor | DMI BIOSCIENCES, INC. | 2012-09-11 | — | — | US | disclosed |
| US-8188215-B2 | Metal-binding compounds and uses therefor | AMPIO PHARMACEUTICALS, INC. | 2012-05-29 | — | — | US | disclosed |
| US-20100144644-A1 | METAL-BINDING COMPOUNDS AND USES THEREFOR | DMI LIFE SCIENCES INC. (US) | 2010-06-10 | — | — | US | disclosed |
| US-7632803-B2 | Metal-binding compounds and uses therefor | DMI LIFE SCIENCES, INC. (US) | 2009-12-15 | — | — | US | disclosed |
| US-7592304-B2 | Metal-binding compounds and uses therefor | DMI LIFE SCIENCES, INC. (US) | 2009-09-22 | — | — | US | disclosed |
| US-20080207562-A1 | Conjugates of Hydroxyalkyl Starch and Active Substance, Prepared by Chemical Ligation Via Thiazolidine | FRESENIUS KABI DEUTSCHLAND GMBH (DE) | 2008-08-28 | — | — | US | disclosed |
| EP-1933878-A2 | CONJUGATES OF HYDROXYALKYL STARCH AND AN ACTIVE SUBSTANCE, PREPARED BY CHEMICAL LIGATION VIA THIAZOLIDINE | Fresenius Kabi Deutschland GmbH (DE) | 2008-06-25 | — | — | EP | disclosed |
| WO-2007067247-A1 | POLYARYLATE COMPOSITIONS USEFUL AS COATINGS , THEIR PREPARATION, AND ARTICLES MADE THEREFROM | GENERAL ELECTRIC COMPANY (US) | 2007-06-14 | — | — | WO | disclosed |
| WO-2007031266-A2 | CONJUGATES OF HYDROXYALKYL STARCH AND AN ACTIVE SUBSTANCE, PREPARED BY CHEMICAL LIGATION VIA THIAZOLIDINE | FRESENIUS KABI DEUTSCHLAND GMBH (DE) | 2007-03-22 | — | — | WO | disclosed |
| EP-1762250-A1 | Conjugates of hydroxyalkyl starch and an active substance, prepared by chemical ligation via thiazolidine | Fresenius Kabi Deutschland GmbH (DE) | 2007-03-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160311842-A1 | ALLOSTERIC MODULATORS OF FACTOR XIa AS ANTICOAGULANT AGENTS | TFPI, TFPI2, F10 | ALDH1A1 4470/4885F2 5/4885LMNA 4253/4885 |
| US-20080207562-A1 | Conjugates of Hydroxyalkyl Starch and Active Substance, Prepared by Chemical Ligation Via Thiazolidine | HACL2, AGL, TTL | ALDH1A1 312/4885F2 1184/4885LMNA 1837/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.