Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.84 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.84 |
| ▸ | TP53 | P04637 | 3/20 | 0.84 |
| ▸ | HSD17B10 | Q99714 | 9/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.76 |
| ▸ | HPGD | P15428 | 8/20 | 0.76 |
| ▸ | GAA | P10253 | 7/20 | 0.76 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.76 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.76 |
| ▸ | MEN1 | O00255 | 3/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.75 |
| ▸ | GLA | P06280 | 4/20 | 0.70 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4753357 | 0.93 | MAPT (0.81) | MAPTSMN1; SMN2TP53HSD17B10ALDH1A1 | |
| SCHEMBL4753163 | 0.87 | HSD17B10 (0.74) | MAPTSMN1; SMN2TP53HSD17B10ALDH1A1 | |
| SCHEMBL4902410 | 0.79 | HSD17B10 (0.77) | MAPTSMN1; SMN2TP53HSD17B10ALDH1A1 | |
| SCHEMBL13362284 | 0.73 | HSD17B10 (0.59) | MAPTSMN1; SMN2TP53HSD17B10ALDH1A1 | |
| SCHEMBL10073027 | 0.73 | HSD17B10 (0.58) | MAPTSMN1; SMN2TP53HSD17B10ALDH1A1 | |
| SCHEMBL4954775 | 0.68 | HPGD (0.53) | MAPTSMN1; SMN2TP53HSD17B10ALDH1A1 | |
| SCHEMBL18832845 | 0.67 | MAPT (1.00) | MAPTSMN1; SMN2TP53ALDH1A1KDM4E | |
| SCHEMBL16311097 | 0.65 | TSHR (0.68) | MAPTSMN1; SMN2TP53HSD17B10ALDH1A1 | |
| SCHEMBL10724385 | 0.65 | ALDH1A1 (1.00) | MAPTSMN1; SMN2TP53HSD17B10ALDH1A1 | |
| SCHEMBL23244275 | 0.64 | ALDH1A1 (0.54) | SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008147864-A2 | METHODS OF USING PIPERAZINE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-12-04 | — | — | WO | disclosed |