Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.81 |
| ▸ | TP53 | P04637 | 3/20 | 0.81 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.76 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.72 |
| ▸ | HPGD | P15428 | 7/20 | 0.72 |
| ▸ | GAA | P10253 | 6/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.72 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.72 |
| ▸ | MEN1 | O00255 | 2/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.70 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | HTT | P42858 | 1/20 | 0.68 |
| ▸ | GLA | P06280 | 3/20 | 0.66 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4752756 | 0.93 | MAPT (0.84) | MAPTTP53SMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL4902410 | 0.87 | HSD17B10 (0.77) | MAPTTP53SMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL4753163 | 0.82 | HSD17B10 (0.74) | MAPTTP53SMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL13362284 | 0.71 | HSD17B10 (0.59) | MAPTTP53SMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL10073027 | 0.70 | HSD17B10 (0.58) | MAPTTP53SMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL4954775 | 0.69 | HPGD (0.53) | MAPTTP53SMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL29748988 | 0.65 | USP2 (0.76) | MAPTTP53SMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL13961792 | 0.64 | TP53 (1.00) | MAPTTP53LMNAPOLB | |
| SCHEMBL23244275 | 0.64 | ALDH1A1 (0.54) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL29576914 | 0.64 | ALDH1A1 (0.54) | SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008147864-A2 | METHODS OF USING PIPERAZINE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-12-04 | — | — | WO | disclosed |