Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 2/20 | 0.31 |
| ▸ | CA1 | P00915 | 2/20 | 0.31 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
| ▸ | MMP2 | P08253 | 2/20 | 0.31 |
| ▸ | CA9 | Q16790 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.30 |
| ▸ | ACACB | O00763 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4973787 | 1.00 | SMN1; SMN2 (0.33) | SMN1; SMN2PKMGAAHPGDCA12 | |
| SCHEMBL4972570 | 0.95 | CA12 (0.33) | SMN1; SMN2CA12CA1CA2MMP2 | |
| SCHEMBL4974662 | 0.95 | CA12 (0.33) | SMN1; SMN2CA12CA1CA2MMP2 | |
| SCHEMBL4972141 | 0.90 | MAPK1 (0.30) | — | |
| SCHEMBL4975234 | 0.83 | SMN1; SMN2 (0.32) | SMN1; SMN2PKMGAAHPGDCA12 | |
| SCHEMBL4975006 | 0.82 | PKM (0.31) | SMN1; SMN2PKMGAAHPGD | |
| SCHEMBL15562277 | 0.81 | CA12 (0.41) | SMN1; SMN2GAAHPGDCA12CA1 | |
| SCHEMBL4975541 | 0.81 | CA12 (0.44) | SMN1; SMN2GAAHPGDCA12CA1 | |
| SCHEMBL14910147 | 0.77 | EPHX2 (0.40) | SMN1; SMN2HPGDCA12CA1CA2 | |
| SCHEMBL1439228 | 0.77 | EPHX2 (0.40) | SMN1; SMN2HPGDCA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008156832-A2 | RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2008-12-24 | — | — | WO | disclosed |